Recombinant human DAP10/HCST protein
HCST, also known as hematopoietic cell signal transducer isoform 1, is a member of the DAP10 family. It can be part of an immunoreceptor complex. This receptor plays an important role in inducing cytotoxicity against MHC class I chain-associated MICA and target cells expressing cell surface ligands such as MICB and UL16-binding protein (ULBP) . This receptor complex can play a role in cell survival and proliferation by activation of NK and T cell responses. Recombinant human HCST, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Hematopoietic cell signal transducer isoform 1, HCST, DAP10, KAP10, PIK3AP
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
30.1 kDa (271aa)
Additionnal Information
References & Citations
Karimi M., et al. (2006) J Immunol. 175:7819-7828.; ; Andre P., et al. (2004) Eur J Immunol. 34:961-971.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_055081
Uniprot Accession Number
Q9UBK5
Species
Human
N Terminal Sequence
Ala
AA Sequence
TTPGERS SLPAFYPGTS GSCSGCGSLS LP
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