Recombinant human TGF-beta RI/ALK-5 protein

TGFBR1, also known as TGF-beta receptor type-1 isoform 1, is a single-pass type 1 membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. This protein is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Also, it plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Diets syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5) . Recombinant human TGFBR1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

TGF-beta receptor type-1 isoform 1, TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

38kDa (342aa)

Additionnal Information

TGF-b RI, ALK5, TGF-beta receptor type-1 isoform 1, TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1, ATGP3735-10 µg, ATGP3735-20 µg, ATGP3735-50 µg, ATGP3735-100 µg, ATGP3735-250 µg, ATGP3735-500 µg, ATGP3735-1 mg, ATGP3735-10, ATGP3735-20, ATGP3735-50, ATGP3735-100, ATGP3735-250, ATGP3735-500, ATGP3735-1