Recombinant human IL-1R beta/IL1R2 protein

IL1R2, also known as interleukin-1 receptor type 2 isoform 1, is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is expressed predominantly by, T cells, fibroblasts and endothelial cells. It binds interleukin-1 alpha (IL1A), interleukin-1beta (IL1B), and interleukin 1 receptor antagonist (IL1RN), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. Also, Interleukin-4 (IL4) is reported to antagonize the activity of interleukin-1 by inducing the expression and release of this cytokine. Recombinant human IL1R2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤400 ng/mL with Human IL-1 beta/IL-1F2.

Product Name Alternative

Interleukin-1 receptor type 2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, IL1RB

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Bioactivity

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤400 ng/mL with Human IL-1 beta/IL-1F2.

Molecular Weight

38.8 kDa (338aa)

Additionnal Information

IL1 RII, ATGP3733-10 µg, ATGP3733-20 µg, ATGP3733-50 µg, ATGP3733-100 µg, ATGP3733-250 µg, ATGP3733-500 µg, ATGP3733-1 mg, ATGP3733-10, ATGP3733-20, ATGP3733-50, ATGP3733-100, ATGP3733-250, ATGP3733-500, ATGP3733-1