Recombinant human CD55/DAF protein
CD55, also known as complement decay-accelerating factor isoform 1, is a membrane protein that attaches to cell membrane via a glycophosphatidylinositol (GPI) anchor. It contains four complement control protein repeats (CCPs) with a single N-linked glycan positioned between CCPs 1 and 2. It regulates the complement system on the cell surface. It is used as a receptor by some coxsackieviruses and other enteroviruses. It is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system. It plays a role promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. Recombinant human CD55, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Complement decay-accelerating factor isoform 1, CD55, CHAPLE, CR, CROM, DAF, TC
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
36 kDa (328aa)
Additionnal Information
References & Citations
Ozen A., et al. (2017) N Engl J Med. 377:52-61.; ; Brodbeck WG., et al. (2000) Immunology. 101:104-111.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000565
Uniprot Accession Number
P08174
Species
Human
N Terminal Sequence
Ala
AA Sequence
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