Recombinant human PDGF R beta protein

PDGFRB, also known as platelet-derived growth factor receptor beta, is a member of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3-ligand. It plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. It promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. It phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Recombinant human PDGFRB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Platelet-derived growth factor receptor beta, PDGFRB, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

83.3 kDa (739aa)

Additionnal Information

PDGF R b, Platelet-derived growth factor receptor beta, PDGFRB, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, ATGP3721-10 µg, ATGP3721-20 µg, ATGP3721-50 µg, ATGP3721-100 µg, ATGP3721-250 µg, ATGP3721-500 µg, ATGP3721-1 mg, ATGP3721-10, ATGP3721-20, ATGP3721-50, ATGP3721-100, ATGP3721-250, ATGP3721-500, ATGP3721-1