Recombinant human IL-3R alpha/IL3RA protein

IL3RA, also known as interleukin 3 receptor subunit alpha isoform 1, is a single-pass type 1 membrane protein which belongs to the type 1 cytokine receptor family and type 5 subfamily. This protein is a pleiotropic cytokine produced primarily by activated T cells or mast cells. Also, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recombinant human IL3RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 3 receptor subunit alpha isoform 1, IL3RA, CD123, hIL-3Ra, IL3R

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

34.1 kDa (295aa)

Additionnal Information

Interleukin-3 receptor subunit alpha isoform 1, Interleukin3 receptor subunit alpha isoform 1, Interleukin 3 receptor subunit alpha isoform 1, IL3RY, IL3RX, IL3RAY, IL3RA, IL3R, hIL-3Ra, Hil3Ra, Hil 3Ra, CD123, ATGP3712-10 µg, ATGP3712-20 µg, ATGP3712-50 µg, ATGP3712-100 µg, ATGP3712-250 µg, ATGP3712-500 µg, ATGP3712-1 mg, ATGP3712-010, ATGP3712-020, ATGP3712-050, ATGP3712-100, ATGP3712-250, ATGP3712-500, ATGP3712-01M

References & Citations

Kosugi H., et al, (1995) Biochem. Biophys. Res. Commun. 208:360-367.; ; Yoshimura A., et al, (1995) EMBO J. 14:2816-2826.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_002174

Uniprot Accession Number

P26951

Species

Human

N Terminal Sequence

Ala

AA Sequence

KEDPNPP ITNLRMKAKA QQLTWDLNRN VTDIECVKDA DYSMPAVNNS YCQFGAISLC EVTNYTVRVA NPPFSTWILF PENSGKPWAG AENLTCWIHD VDFLSCSWAV GPGAPADVQY DLYLNVANRR QQYECLHYKT DAQGTRIGCR FDDISRLSSG SQSSHILVRG RSAAFGIPCT DKFVVFSQIE ILTPPNMTAK CNKTHSFMHW KMRSHFNRKF RYELQIQKRM QPVITEQVRD RTSFQLLNPG TYTVQIRARE RVYEFLSAWS TPQRFECDQE EGANTRAWR