Recombinant human Siglec-2/CD22 protein
CD22, also known as B-cell receptor CD22 isoform 1, is a member of the immunoglobulin (Ig) superfamily. It mediates B-cell to B-cell interactions and is involved in the localization of B-cells in lymphoid tissues. This protein plays a positive regulation through interaction with Src family tyrosine kinases and also acts as an inhibitory receptor by recruiting cytoplasmic phosphatases. Recombinant human CD22 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
B-cell receptor CD22 isoform 1, CD22, SIGLEC-2, SIGLEC2
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
102.1 kDa (907aa)
Additionnal Information
References & Citations
Yu SF., et al, (2015) Clin Cancer Res. 21:3298-3306.; ; Lumb S., et al, (2016) J Cell Commun Signal. 10:143-151.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001762
Uniprot Accession Number
P20273
Species
Human
N Terminal Sequence
Asp20
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