Recombinant human SLP-76/LCP2 protein

LCP2, also known as lymphocyte cytosolic protein 2, is an intracellular docking protein with a single SH2 recognition domain. It is involved in T-cell antigen receptor mediated signaling. This protein is phosphorylated by ZAP70 leading to NF-AT and IL2 gene activation. Recombinant human LCP2 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Lymphocyte cytosolic protein 2, LCP2, SLP-76, SLP76

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

61.2 kDa (542aa)

Additionnal Information

SLP76, LCP2, Lymphocyte cytosolic protein 2, LCP2, SLP-76, SLP76, ATGP3706-10 µg, ATGP3706-20 µg, ATGP3706-50 µg, ATGP3706-100 µg, ATGP3706-250 µg, ATGP3706-500 µg, ATGP3706-1 mg, ATGP3706-10, ATGP3706-20, ATGP3706-50, ATGP3706-100, ATGP3706-250, ATGP3706-500, ATGP3706-1

References & Citations

Siggs OM., et al, (2015) J Immunol. 194:2587-2595.; ; Danzer C., et al, (2016) Eur J Immunol. 46:2121-2136.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_005556

Uniprot Accession Number

Q13094

Species

Human

N Terminal Sequence

Ala

AA Sequence

MALRNVP FRSEVLGWDP DSLADYFKKL NYKDCEKAVK KYHIDGARFL NLTENDIQKF PKLRVPILSK LSQEINKNEE RRSIFTRKPQ VPRFPEETES HEEDNGGWSS FEEDDYESPN DDQDGEDDGD YESPNEEEEA PVEDDADYEP PPSNDEEALQ NSILPAKPFP NSNSMYIDRP PSGKTPQQPP VPPQRPMAAL PPPPAGRNHS PLPPPQTNHE EPSRSRNHKT AKLPAPSIDR STKPPLDRSL APFDREPFTL GKKPPFSDKP SIPAGRSLGE HLPKIQKPPL PPTTERHERS SPLPGKKPPV PKHGWGPDRR ENDEDDVHQR PLPQPALLPM SSNTFPSRST KPSPMNPLPS SHMPGAFSES NSSFPQSASL PPYFSQGPSN RPPIRAEGRN FPLPLPNKPR PPSPAEEENS LNEEWYVSYI TRPEAEAALR KINQDGTFLV RDSSKKTTTN PYVLMVLYKD KVYNIQIRYQ KESQVYLLGT GLRGKEDFLS VSDIIDYFRK MPLLLIDGKN RGSRYQCTLT HAAGYP