Recombinant human TIGIT protein

TIGIT, also known as T-cell immunoreceptor with Ig and ITIM domains, is a surface protein containing and immunoglobulin variable domain. This protein is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells. Also, it binds with high affinity to the poliovirus receptor which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Recombinant human TIGIT, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

T-cell immunoreceptor with Ig and ITIM domains, TIGIT, VSIG9, VSTM3, WUCAM

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

40kDa (359aa)

Additionnal Information

TIGIT, T-cell immunoreceptor with Ig and ITIM domains, TIGIT, VSIG9, VSTM3, WUCAM, ATGP3704-10 µg, ATGP3704-20 µg, ATGP3704-50 µg, ATGP3704-100 µg, ATGP3704-250 µg, ATGP3704-500 µg, ATGP3704-1 mg, ATGP3704-10, ATGP3704-20, ATGP3704-50, ATGP3704-100, ATGP3704-250, ATGP3704-500, ATGP3704-1