Recombinant human IL-7R alpha/IL7R protein

IL7R, also known as interleukin-7 receptor, is a hematopoietin receptor superfamily member. It plays important role in lymphocyte differentiation, proliferation, multiple sclerosis, and survival. This protein signaling is essential for T-cell development and regulation of native and memory T-cell homeostasis. Also, it is critically required for the proper development and function of lymphoid cells. Recombinant human IL7R, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 7 receptor, Interleukin-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, CD127, CDw127, lnc-IL7R

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

52.5 kDa (461aa)

Additionnal Information

IL7 R a, CD127, ATGP3703-10 µg, ATGP3703-20 µg, ATGP3703-50 µg, ATGP3703-100 µg, ATGP3703-250 µg, ATGP3703-500 µg, ATGP3703-1 mg, ATGP3703-10, ATGP3703-20, ATGP3703-50, ATGP3703-100, ATGP3703-250, ATGP3703-500, ATGP3703-1

References & Citations

Goodwin RG., et al, (1990) Cell 60:941-951.; ; Melao A., et al, (2016) Haematologica 101:1368-1379.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_002176

Uniprot Accession Number

P16871

Species

Human

N Terminal Sequence

Ala

AA Sequence

ESGYAQN GDLEDAELDD YSFSCYSQLE VNGSQHSLTC AFEDPDVNIT NLEFEICGAL VEVKCLNFRK LQEIYFIETK KFLLIGKSNI CVKVGEKSLT CKKIDLTTIV KPEAPFDLSV VYREGANDFV VTFNTSHLQK KYVKVLMHDV AYRQEKDENK WTHVNLSSTK LTLLQRKLQP AAMYEIKVRS IPDHYFKGFW SEWSPSYYFR TPEINNSSGE MD