Recombinant mouse SF20/MYDGF protein
Mydgf, also known as Myeloid-derived growth factor, is a bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and repair after myocardial infarction. It stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Mydgf-deficient mice develop larger infarct scars and more severe contractile dysfunction compared to wild-type mice. Recombinant mouse Mydgf, fused to His-tag at N-termineus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Myeloid-derived growth factor, D17Wsu104e, Il25, Ly6elg
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Purity
> 95% by SDS-PAGE
Molecular Weight
18.1 kDa (165aa) Confirmed by MALDI-TOF
Additionnal Information
References & Citations
Korf-Klingebiel M., et al. (2015) Nat Med. 21 (2) :140-9; ; Weiler T., et al. (2007) Arthritis Res Ther. 9 (2) :R30.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_543027
Uniprot Accession Number
Q9CPT4
Species
Mouse
AA Sequence
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