Recombinant human CDK5 protein
CDK5, also known as cyclin-dependent-like kinase 5 isoform 1, is a member of the cyclin dependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. This is activated by association with a neuron-specific activator, p35 or its isoform p39. CDK5 is probably involved in the control of the cell cycle. Recombinant human CDK5 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cyclin-dependent-like kinase 5 isoform 1, CDK5, LIS7, PSSALRE
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.1 kDa (298aa)
Additionnal Information
References & Citations
Shupp A., et al, (2017) Oncotarget. 8:17373-17382.; ; Na YR., et al, (2015) Sci Signal. 8:ra121.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 40% glycerol, 1mM DTT
Scientific Category
Cell Cycle
NCBI Accession Number
NP_004926
Uniprot Accession Number
Q00535
Species
Human
N Terminal Sequence
Met1
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