Recombinant human CD107b/LAMP2 protein

LAMP2, also known as lysosome-associated membrane glycoprotein 2 isoform A, is a major component of lysosomal membranes. It provides selectins with carbohydrate ligands. This protein mediates the lysosomal uptake of the chaperone HSC73 in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles. Deficiency of LAMP2 is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. Recombinant human LAMP2 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, CD107b, Lysosomal membrane glycoprotein type B, LGP-B

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

39.4 kDa (356aa)

Additionnal Information

Lysosome-associated membrane protein 2, Lysosome-associated membrane glycoprotein 2 isoform A, Lysosome-associated membrane glycoprotein 2, Lysosome associated membrane protein 2, Lysosome associated membrane glycoprotein 2 isoform A, Lysosome associated membrane glycoprotein 2, Lysosomal membrane glycoprotein type B, LGP-B, LGPB, LGP-96, LGP96, LGP-110, LGP110, LGP B, LGP 96, LGP 110, LAMP-B, LAMPB, LAMP-2, LAMP2, LAMP B, LAMP 2, CD107b, CD107 antigen-like family member B, CD107 antigen like family member B, ATGP3680-10 µg, ATGP3680-20 µg, ATGP3680-50 µg, ATGP3680-100 µg, ATGP3680-250 µg, ATGP3680-500 µg, ATGP3680-1 mg, ATGP3680-010, ATGP3680-020, ATGP3680-050, ATGP3680-100, ATGP3680-250, ATGP3680-500, ATGP3680-01M

References & Citations

Mello AS., et al, (2014) Mol Cell Biochem. 385:1-6.; ; Damaghi M., et al, (2015) Nat Commun. 6:8752.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_002285

Uniprot Accession Number

P13473

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPLELNLTD SENATCLYAK WQMNFTVRYE TTNKTYKTVT ISDHGTVTYN GSICGDDQNG PKIAVQFGPG FSWIANFTKA ASTYSIDSVS FSYNTGDNTT FPDAEDKGIL TVDELLAIRI PLNDLFRCNS LSTLEKNDVV QHYWDVLVQA FVQNGTVSTN EFLCDKDKTS TVAPTIHTTV PSPTTTPTPK EKPEAGTYSV NNGNDTCLLA TMGLQLNITQ DKVASVININ PNTTHSTGSC RSHTALLRLN SSTIKYLDFV FAVKNENRFY LKEVNISMYL VNGSVFSIAN NNLSYWDAPL GSSYMCNKEQ TVSVSGAFQI NTFDLRVQPF NVTQGKYSTA QDCSADDDNF HHHHHH