Recombinant human CD98 protein

SLC3A2, also known as 4F2 cell-surface antigen heavy chain isoform c, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. It is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. This protein is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. This protein involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. Recombinant human SLC3A2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

4F2 cell-surface antigen heavy chain isoform c, SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

47.9 kDa (434aa)

Additionnal Information

CD98, 4F2 cell-surface antigen heavy chain isoform c, SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE, ATGP3676-10 µg, ATGP3676-20 µg, ATGP3676-50 µg, ATGP3676-100 µg, ATGP3676-250 µg, ATGP3676-500 µg, ATGP3676-1 mg, ATGP3676-10, ATGP3676-20, ATGP3676-50, ATGP3676-100, ATGP3676-250, ATGP3676-500, ATGP3676-1

References & Citations

Mastroberardino L., et al. (1998) Nature. 395:288-291.; ; Fort J., et al. (2007) J Biol Chem. 282:31444-31452.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_002385

Uniprot Accession Number

P08195

Species

Human

N Terminal Sequence

Ala

AA Sequence

RAPRCRE LPAQKWWHTG ALYRIGDLQA FQGHGAGNLA GLKGRLDYLS SLKVKGLVLG PIHKNQKDDV AQTDLLQIDP NFGSKEDFDS LLQSAKKKSI RVILDLTPNY RGENSWFSTQ VDTVATKVKD ALEFWLQAGV DGFQVRDIEN LKDASSFLAE WQNITKGFSE DRLLIAGTNS SDLQQILSLL ESNKDLLLTS SYLSDSGSTG EHTKSLVTQY LNATGNRWCS WSLSQARLLT SFLPAQLLRL YQLMLFTLPG TPVFSYGDEI GLDAAALPGQ PMEAPVMLWD ESSFPDIPGA VSANMTVKGQ SEDPGSLLSL FRRLSDQRSK ERSLLHGDFH AFSAGPGLFS YIRHWDQNER FLVVLNFGDV GLSAGLQASD LPASASLPAK ADLLLSTQPG REEGSPLELE RLKLEPHEGL LLRFPYAA