Recombinant human CD94/KLRD1 protein
KLRD1, also known as natural killer cells antigen CD94 isoform 1, is expressed on the surface of natural killer cells in the innate immune system. It plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. This protein can form disulfide-bonded heterodimer with NKG2 family members. CD94 and NKG2 complex interacts with Human Leukocyte Antigen (HLA) -E on target cells on the surface of natural killer cells. Recombinant human KLRD1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Killer cell lectin like receptor D1, Natural killer cells antigen CD94, KP43, Killer cell lectin-like receptor subfamily D member 1, NK cell receptor
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
18.2 kDa (157aa)
Additionnal Information
References & Citations
Phillips JH., et al, (1996) Immunity 5:163-172.; ; Brooks AG., et al, (1997) J. Exp. Med. 185:795-800.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_002253
Uniprot Accession Number
Q13241
Species
Human
N Terminal Sequence
Ala
AA Sequence
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