Recombinant human DDR1 protein
DDR1, also known as epithelial discoidin domain-containing receptor 1 isoform 2, is a transmembrane glycoprotein that belongs to the discoidin-like domain containing subfamily of receptor tyrosine kinases. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1 oligomerization enhances collagen binding and also modulates collagen fibrillogenesis. Recombinant human DDR1 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Epithelial discoidin domain-containing receptor 1 isoform 2, DDR1, CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
71kDa (636aa)
Additionnal Information
References & Citations
Ambrogio C., et al, (2016) Nat Med. 22:270-277.; ; Song J., et al, (2016) Tumour Biol. 37:11509-11521.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_054699
Uniprot Accession Number
Q08345
Species
Human
N Terminal Sequence
Asp21
AA Sequence
Frequently Asked Questions
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