Recombinant human CD89/FCAR protein
FCAR, also known as immunoglobulin alpha Fc receptor isoform, is a member of the multichain immune recognition receptor family which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. It plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. It is also an important Fc receptor for neutrophil killing of tumor cells. When FCAR expressing neutrophils come into contact with IgA-opsonized tumor cells, the neutrophils not only perform antibody-dependent cell-mediated cytotoxicity, but also release the cytokines TNF-alpha and IL-1beta which cause increased neutrophil migration to the site. Recombinant human FCAR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CD89, CTB-61M7.2, Fc alpha receptor, Fc fragment of IgA receptor, FcalphaR, FcalphaRI, FCAR, IgA Fc receptor, Immunoglobulin alpha Fc receptor isoform
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
24.5 kDa (215aa)
Additionnal Information
References & Citations
Maliszewski, C. R., et al. (1990) J. Exp. Med. 172:1665-1672.; ; Kanamaru, Y., et al. (2007) Blood. 109:203-211.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001991
Uniprot Accession Number
P24071
Species
Human
N Terminal Sequence
Ala
AA Sequence
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