Recombinant human HMGCL protein

HMGCL, also known as hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1, is a mitochondrial matrix protein that belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Multiple isoforms of the proteins are known due to alternative splicing. The major isoform (isoform 1) is most highly expressed in the liver whereas isoform 2 is found in energy-demanding tissues including the brain, heart, and skeletal muscle. Recombinant human HMGCL protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1, HMGCL, HL

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

32.5 kDa (305aa)

Additionnal Information

HMGCL, Hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1, HMGCL, HL, ATGP3658-10 µg, ATGP3658-20 µg, ATGP3658-50 µg, ATGP3658-100 µg, ATGP3658-250 µg, ATGP3658-500 µg, ATGP3658-1 mg, ATGP3658-10, ATGP3658-20, ATGP3658-50, ATGP3658-100, ATGP3658-250, ATGP3658-500, ATGP3658-1