Recombinant human CD155/PVR protein
PVR, also known as poliovirus receptor isoform alpha, is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. It catalyzes a large structural change in the virus that exposes membrane-binding protein chains. It plays an important regulatory role in helper T cell differentiation and allergic diseases. It is expressed in many types of human cells and has diverse functions. It may be potentially useful as a biomarker for cancer development and progression. It may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer. Recombinant human PVR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Poliovirus receptor isoform alpha, PVR, CD155, HVED, Necl-5, NECL5, PVS, TAGE4, PVR cell adhesion molecule, Nectin-like protein 5
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
36.1 kDa (331aa)
Additionnal Information
References & Citations
Nishiwada S., et al. (2015) Anticancer Res. 35:2287-2297.; ; Strauss M., et al. (2015) J Virol. 89:4143-4157.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_006496
Uniprot Accession Number
P15151
Species
Human
N Terminal Sequence
Trp21
AA Sequence
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