Recombinant human CD155/PVR protein

PVR, also known as poliovirus receptor isoform alpha, is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. It catalyzes a large structural change in the virus that exposes membrane-binding protein chains. It plays an important regulatory role in helper T cell differentiation and allergic diseases. It is expressed in many types of human cells and has diverse functions. It may be potentially useful as a biomarker for cancer development and progression. It may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer. Recombinant human PVR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Poliovirus receptor isoform alpha, PVR, CD155, HVED, Necl-5, NECL5, PVS, TAGE4, PVR cell adhesion molecule, Nectin-like protein 5

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

36.1 kDa (331aa)

Additionnal Information

PVR, Poliovirus receptor isoform alpha, PVR, CD155, HVED, Necl-5, NECL5, PVS, TAGE4, ATGP3644-10 µg, ATGP3644-20 µg, ATGP3644-50 µg, ATGP3644-100 µg, ATGP3644-250 µg, ATGP3644-500 µg, ATGP3644-1 mg, ATGP3644-10, ATGP3644-20, ATGP3644-50, ATGP3644-100, ATGP3644-250, ATGP3644-500, ATGP3644-1

References & Citations

Nishiwada S., et al. (2015) Anticancer Res. 35:2287-2297.; ; Strauss M., et al. (2015) J Virol. 89:4143-4157.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_006496

Uniprot Accession Number

P15151

Species

Human

N Terminal Sequence

Trp21

AA Sequence

WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGM SRNLEHHHHH H