Recombinant human Nectin-2/CD112 protein

NECTIN2, also known as nectin-2 isoform delta, is a Ca (2+) -independent cell-cell adhesion molecule that is one of the plasma membrane components of adherens junctions. It is a key player for the establishment of homotypic and heterotypic cell to cell contacts. It is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. It is a potential target for antibody therapy of breast and ovarian cancers. It might be associated with human longevity. Recombinant human NECTIN2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Nectin-2 isoform delta, NECTIN2, CD112, HVEB, PRR2, PVRL2, PVRR2

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

36.3 kDa (337aa)

Additionnal Information

Nectin2, CD112, Nectin-2 isoform delta, NECTIN2, CD112, HVEB, PRR2, PVRL2, PVRR2, ATGP3641-10 µg, ATGP3641-20 µg, ATGP3641-50 µg, ATGP3641-100 µg, ATGP3641-250 µg, ATGP3641-500 µg, ATGP3641-1 mg, ATGP3641-10, ATGP3641-20, ATGP3641-50, ATGP3641-100, ATGP3641-250, ATGP3641-500, ATGP3641-1

References & Citations

Devilard E., et al. (2013) PLoS One. 8:e77424.; ; Oshima T., et al. (2013) Mol Cancer. 12:60.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001036189

Uniprot Accession Number

Q92692

Species

Human

N Terminal Sequence

Gln32

AA Sequence

QDVRVQVLPE VRGQLGGTVE LPCHLLPPVP GLYISLVTWQ RPDAPANHQN VAAFHPKMGP SFPSPKPGSE RLSFVSAKQS TGQDTEAELQ DATLALHGLT VEDEGNYTCE FATFPKGSVR GMTWLRVIAK PKNQAEAQKV TFSQDPTTVA LCISKEGRPP ARISWLSSLD WEAKETQVSG TLAGTVTVTS RFTLVPSGRA DGVTVTCKVE HESFEEPALI PVTLSVRYPP EVSISGYDDN WYLGRTDATL SCDVRSNPEP TGYDWSTTSG TFPTSAVAQG SQLVIHAVDS LFNTTFVCTV TNAVGMGRAE QVIFVRETPN TAGAGATGGL EHHHHHH