Recombinant human Nectin-2/CD112 protein
NECTIN2, also known as nectin-2 isoform delta, is a Ca (2+) -independent cell-cell adhesion molecule that is one of the plasma membrane components of adherens junctions. It is a key player for the establishment of homotypic and heterotypic cell to cell contacts. It is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. It is a potential target for antibody therapy of breast and ovarian cancers. It might be associated with human longevity. Recombinant human NECTIN2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Nectin-2 isoform delta, NECTIN2, CD112, HVEB, PRR2, PVRL2, PVRR2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
36.3 kDa (337aa)
Additionnal Information
References & Citations
Devilard E., et al. (2013) PLoS One. 8:e77424.; ; Oshima T., et al. (2013) Mol Cancer. 12:60.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001036189
Uniprot Accession Number
Q92692
Species
Human
N Terminal Sequence
Gln32
AA Sequence
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