Recombinant human IL-13R alpha 2/IL13RA2 protein

IL13RA2, also known as interleukin-13 receptor subunit alpha-2, is a membrane bound protein that in humans is encoded by the IL13RA2 gene. It is able to regulate the effects of both IL13 and IL14, despite the fact it is unable to bind directly to the latter. Also, this protein plays an important role in the Th2-polarized immune responses characteristic of a variety of pathologies, including parasitic infection and allergic asthma. Recombinant human IL13RA2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 13 receptor subunit alpha 2, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, IL-13R-alpha-2, Interleukin-13-binding protein, CD213a2, IL13R, IL13BP, cancer/testis antigen 19, CT19

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

64.3 kDa (559aa)

Additionnal Information

IL13 R a2, ATGP3640-10 µg, ATGP3640-20 µg, ATGP3640-50 µg, ATGP3640-100 µg, ATGP3640-250 µg, ATGP3640-500 µg, ATGP3640-1 mg, ATGP3640-10, ATGP3640-20, ATGP3640-50, ATGP3640-100, ATGP3640-250, ATGP3640-500, ATGP3640-1

References & Citations

Caput D., et al, (1996) J. Biol. Chem. 271:16921-16926.; ; Donaldson DD., et al, (1998) J. Immunol. 161:2317-2324.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_000631.1

Uniprot Accession Number

Q14627

Species

Human

N Terminal Sequence

Ala

AA Sequence

DTEIKVN PPQDFEIVDP GYLGYLYLQW QPPLSLDHFK ECTVEYELKY RNIGSETWKT IITKNLHYKD GFDLNKGIEA KIHTLLPWQC TNGSEVQSSW AETTYWISPQ GIPETKVQDM DCVYYNWQYL LCSWKPGIGV LLDTNYNLFY WYEGLDHALQ CVDYIKADGQ NIGCRFPYLE ASDYKDFYIC VNGSSENKPI RSSYFTFQLQ NIVKPLPPVY LTFTRESSCE IKLKWSIPLG PIPARCFDYE IEIREDDTTL VTATVENETY TLKTTNETRQ LCFVVRSKVN IYCSDDGIWS EWSDKQCWEG EDLSKKTLLR