Recombinant human B7-H3 (4Ig) /B7-H3b protein
CD276, also known as CD276 antigen isoform, is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. It is a costimulatory molecule for T cell activation and IFN-gamma production. It upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu. It is correlated with TNM stage of NSCLC and may serve as a potential biomarker for NSCLC-derived MPEs. Recombinant human CD276, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CD276 antigen isoform, CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
48.1 kDa (446aa)
Additionnal Information
References & Citations
Sun ZZ., et al. (2016) Oncol Rep. 36:231-238.; ; Chen L., et al. (2016) Clin Chim Acta. 457:81-85.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001019907.1
Uniprot Accession Number
Q5ZPR3
Species
Human
N Terminal Sequence
Leu29
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