Recombinant human IL-17R alpha/IL17RA protein
IL17RA, also known as interleukin-17 receptor A isoform 1, is a cytokine receptor which binds interleukin 17. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. It is a type1 membrane glycoprotein that binds with low affinity to interleukin 17A. This protein and Interleukin 17A play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Recombinant human IL17RA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-17 receptor A isoform 1, IL17RA, CANDF5, CD217, CDw217, hIL-17R, IL-17RA, IL17R, IMD51, Macrophagleukin-17 receptor 2
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
60.4 kDa (527aa)
Additionnal Information
References & Citations
Honorati MC., et al, (2001) Rheumatology 40:522-527.; ; Yao Z., et al, (1997) Cytokine 9:794-800.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_055154
Uniprot Accession Number
Q96F46
Species
Human
N Terminal Sequence
Leu33
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