Recombinant human VEGF R2/KDR/Flk-1 protein

KDR, also known as vascular endothelial growth factor receptor 2, is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF) . There are three main subtypes of VEGFR (1, 2 and 3) . VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions like cancer. Also, this protein is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Recombinant human KDR protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Vascular endothelial growth factor receptor 2, KDR, CD309, FLK1, VEGFR, VEGFR2

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

110.5 kDa (987aa)

Additionnal Information

VEGF R2, KDR, Flk1, Vascular endothelial growth factor receptor 2, KDR, CD309, FLK1, VEGFR, VEGFR2, ATGP3627-10 µg, ATGP3627-20 µg, ATGP3627-50 µg, ATGP3627-100 µg, ATGP3627-250 µg, ATGP3627-500 µg, ATGP3627-1 mg, ATGP3627-10, ATGP3627-20, ATGP3627-50, ATGP3627-100, ATGP3627-250, ATGP3627-500, ATGP3627-1

References & Citations

Han KY., et al, (2009) Biochem Biophys Res Commun. 382:124-128.; ; Takyar S., et al, (2016) FASEB J. 30:1317-1327.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_002244.1

Uniprot Accession Number

P35968

Species

Human

N Terminal Sequence

Ala

AA Sequence

ASVGLPS VSLDLPRLSI QKDILTIKAN TTLQITCRGQ RDLDWLWPNN QSGSEQRVEV TECSDGLFCK TLTIPKVIGN DTGAYKCFYR ETDLASVIYV YVQDYRSPFI ASVSDQHGVV YITENKNKTV VIPCLGSISN LNVSLCARYP EKRFVPDGNR ISWDSKKGFT IPSYMISYAG MVFCEAKIND ESYQSIMYIV VVVGYRIYDV VLSPSHGIEL SVGEKLVLNC TARTELNVGI DFNWEYPSSK HQHKKLVNRD LKTQSGSEMK KFLSTLTIDG VTRSDQGLYT CAASSGLMTK KNSTFVRVHE KPFVAFGSGM ESLVEATVGE RVRIPAKYLG YPPPEIKWYK NGIPLESNHT IKAGHVLTIM EVSERDTGNY TVILTNPISK EKQSHVVSLV VYVPPQIGEK SLISPVDSYQ YGTTQTLTCT VYAIPPPHHI HWYWQLEEEC ANEPSQAVSV TNPYPCEEWR SVEDFQGGNK IEVNKNQFAL IEGKNKTVST LVIQAANVSA LYKCEAVNKV GRGERVISFH VTRGPEITLQ PDMQPTEQES VSLWCTADRS TFENLTWYKL GPQPLPIHVG ELPTPVCKNL DTLWKLNATM FSNSTNDILI MELKNASLQD QGDYVCLAQD RKTKKRHCVV RQLTVLERVA PTITGNLENQ TTSIGESIEV SCTASGNPPP QIMWFKDNET LVEDSGIVLK DGNRNLTIRR VRKEDEGLYT CQACSVLGCA KVEAFFIIEG AQEKTNLE