Recombinant human Syndecan-2/SDC2 protein
SDC2, also known as syndecan 2, is a conserved family of heparan- and chondroitin-sulfate carrying transmembrane protein. It is a cell membrane proteoglycans that can modulate the activity and dynamics of some growth factor receptors and integrins. It is expressed in hepatic stellate cells (HSCs), a key cell type involved in matrix deposition in liver fibrotic disorders. It has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recombinant human SDC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Syndecan 2, SDC2, CD362, HSPG, HSPG1, SYND2, Syndecan proteoglycan 2, Fibroglycan, Heparan sulfate proteoglycan core protein
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
15 kDa (135aa)
Additionnal Information
References & Citations
Renga B., et al. (2014) PLoS One. 9:e94798.; ; Essner JJ., et al. (2006) Int J Biochem Cell Biol. 38:152-156.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_002989
Uniprot Accession Number
P34741
Species
Human
N Terminal Sequence
Ala
AA Sequence
ADPESRAELT SDKDMYLDNS SIEEASGVYP IDDDDYASAS GSGADEDVES PELTTSRPLP KILLTSAAPK VETTTLNIQN KIPAQTKSPE ETDKEKVHLS DSERKMDPAE EDTNVYTEKH SDSLFKRTEH HHHHH
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