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Recombinant human Syndecan-2/SDC2 protein

SDC2, also known as syndecan 2, is a conserved family of heparan- and chondroitin-sulfate carrying transmembrane protein. It is a cell membrane proteoglycans that can modulate the activity and dynamics of some growth factor receptors and integrins. It is expressed in hepatic stellate cells (HSCs), a key cell type involved in matrix deposition in liver fibrotic disorders. It has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recombinant human SDC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Syndecan 2, SDC2, CD362, HSPG, HSPG1, SYND2, Syndecan proteoglycan 2, Fibroglycan, Heparan sulfate proteoglycan core protein

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

15 kDa (135aa)

Additionnal Information

SDC2, Syndecan 2, SDC2, CD362, HSPG, HSPG1, SYND2, ATGP3625-10 µg, ATGP3625-20 µg, ATGP3625-50 µg, ATGP3625-100 µg, ATGP3625-250 µg, ATGP3625-500 µg, ATGP3625-1 mg, ATGP3625-10, ATGP3625-20, ATGP3625-50, ATGP3625-100, ATGP3625-250, ATGP3625-500, ATGP3625-1

References & Citations

Renga B., et al. (2014) PLoS One. 9:e94798.; ; Essner JJ., et al. (2006) Int J Biochem Cell Biol. 38:152-156.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_002989

Uniprot Accession Number

P34741

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPESRAELT SDKDMYLDNS SIEEASGVYP IDDDDYASAS GSGADEDVES PELTTSRPLP KILLTSAAPK VETTTLNIQN KIPAQTKSPE ETDKEKVHLS DSERKMDPAE EDTNVYTEKH SDSLFKRTEH HHHHH

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