Recombinant human TWEAKR/TNFRSF12A protein
TNFRSF12A, also known as tumor necrosis factor receptor superfamily member 12A, is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12) . It is a Downstream Target of the TGF-b Signaling Pathway and regulates Fibroblast Activation. It promotes oxidative stress through NADPH oxidase activation in macrophages. It is responsible for TWEAK-induced proliferation of endothelial cells and angiogenesis. Recombinant human TNFRSF12A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
32.6 kDa (292aa)
Additionnal Information
References & Citations
Nakayama M., et al. (2003) J Immunol. 170:341-348.; ; Madrigal-Matute J., et al. (2015) Cardiovasc Res. 108:139-147.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_057723
Uniprot Accession Number
Q9NP84
Species
Human
N Terminal Sequence
Glu28
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