Recombinant human CD158f/KIR2DL5A protein

KIR2DL5A, also known as killer cell immunoglobulin-like receptor 2DL5A, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. It is detected on the cell surface as a monomer that, upon tyrosine phosphorylation, recruits the Src homology region 2-containing protein tyrosine phosphatase-2, It is thus an inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that it plays a specialized role in innate immunity. Recombinant human KIR2DL5A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Killer cell immunoglobulin-like receptor 2DL5A, KIR2DL5A, CD158F, KIR2DL5A.1, KIR2DL5A.3, Killer cell immunoglobulin like receptor two Ig domains and long cytoplasmic tail 5A

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

50.5 kDa (459aa)

Additionnal Information

KIR2DL5A, Killer cell immunoglobulin-like receptor 2DL5A, KIR2DL5A, CD158F, KIR2DL5A.1, KIR2DL5A.3, ATGP3623-10 µg, ATGP3623-20 µg, ATGP3623-50 µg, ATGP3623-100 µg, ATGP3623-250 µg, ATGP3623-500 µg, ATGP3623-1 mg, ATGP3623-10, ATGP3623-20, ATGP3623-50, ATGP3623-100, ATGP3623-250, ATGP3623-500, ATGP3623-1

References & Citations

Vilches, C., et al. (2000) J. Immunol. 164: 5797-5804.; ; Lanier, L. L., et al. (2005) Rev. Immunol. 23: 187-225.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_065396

Uniprot Accession Number

Q8N109

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPHEGGQDK PLLSAWPSAV VPRGGHVTLL CRSRLGFTIF SLYKEDGVPV PELYNKIFWK SILMGPVTPA HAGTYRCRGS HPRSPIEWSA PSNPLVIVVT GLFGKPSLSA QPGPTVRTGE NVTLSCSSRS SFDMYHLSRE GRAHEPRLPA VPSVNGTFQA DFPLGPATHG GTYTCFGSLH DSPYEWSDPS DPLLVSVTGN SSSSSSSPTE PSSKTGIRRH VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH