Recombinant human CD158f/KIR2DL5A protein
KIR2DL5A, also known as killer cell immunoglobulin-like receptor 2DL5A, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. It is detected on the cell surface as a monomer that, upon tyrosine phosphorylation, recruits the Src homology region 2-containing protein tyrosine phosphatase-2, It is thus an inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that it plays a specialized role in innate immunity. Recombinant human KIR2DL5A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
50.5 kDa (459aa)
Additionnal Information
References & Citations
Vilches, C., et al. (2000) J. Immunol. 164: 5797-5804.; ; Lanier, L. L., et al. (2005) Rev. Immunol. 23: 187-225.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_065396
Uniprot Accession Number
Q8N109
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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