Recombinant human L1CAM protein
L1CAM, also known as neural cell adhesion molecule L1 isoform 3, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. It is now recognized to play a key role in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recombinant human L1CAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neural cell adhesion molecule L1 isoform 3, L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
123.6 kDa (1104aa)
Additionnal Information
References & Citations
Maness, P.F., et al. (2007) Nat. Neurosci. 10:19-26.; ; Gavert, N., et al. (2008) Expert Opin Biol Ther. 8 (11) :1749-57.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001137435
Uniprot Accession Number
P32004
Species
Human
N Terminal Sequence
Ile20
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