Recombinant human IL-2R alpha/IL2RA protein

IL2RA, also known as interleukin-2 receptor subunit alpha isoform 1, is a type 1 transmembrane glycoprotein. This protein is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis and tumor infiltrating lymphocytes. It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia. Also, it is elevated in proliferative disturbances of the hematopoietic system and in many solid tumors. Recombinant human IL2RA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 2 receptor subunit alpha, Insulin-dependent diabetes mellitus 10, Interleukin 2 receptor alpha, IL2R, IDDM10, CD25, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

52.1 kDa (461aa)

Additionnal Information

CD25, IL2 R a, Interleukin-2 receptor subunit alpha isoform 1, IL2RA, CD25, IDDM10, IL2R, IMD41, p55, TCGFR, ATGP3616-10 µg, ATGP3616-20 µg, ATGP3616-50 µg, ATGP3616-100 µg, ATGP3616-250 µg, ATGP3616-500 µg, ATGP3616-1 mg, ATGP3616-10, ATGP3616-20, ATGP3616-50, ATGP3616-100, ATGP3616-250, ATGP3616-500, ATGP3616-1

References & Citations

Kuziel WA., et al, (1990) J. Invest. Dermatol. 94:27S-32S.; ; Purvis SF., et al, (1992) Cell. Immunol. 144:32-42.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_000408

Uniprot Accession Number

P01589

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPELCDDDP PEIPHATFKA MAYKEGTMLN CECKRGFRRI KSGSLYMLCT GNSSHSSWDN QCQCTSSATR NTTKQVTPQP EEQKERKTTE MQSPMQPVDQ ASLPGHCREP PPWENEATER IYHFVVGQMV YYQCVQGYRA LHRGPAESVC KMTHGKTRWT QPQLICTGEM ETSQFPGEEK PQASPEGRPE SETSCLVTTT DFQIQTEMAA TMETSIFTTE YQLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H