Recombinant human IL-17F protein
IL17F, also known as Interleukin-17F, is a cytokine that shares sequence similarity with IL17. It is expressed in activated CD4+ T-cells and activated monocytes. The biological activities mediated by IL17F are similar to those of IL-17. This protein stimulates production of IL-6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis. It also inhibits angiogenesis and induces production of IL-2, TGF-beta, and monocyte chemoattractant protein-1 in endothelial cells Recombinant human IL17F protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CANDF6, IL-17F, Interleukin-17F, Interleukin-2, Macrophagleukin-17F, ML-1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
16kDa (142aa)
Additionnal Information
References & Citations
Fukuyama T., et al, (2012) J Gastrointestin Liver Dis. 21:243-249.; ; Giles DA., et al, (2016) PLoS One. 11:e0149783.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT
Scientific Category
Cardiovascular
NCBI Accession Number
NP_443104
Uniprot Accession Number
Q96PD4
Species
Human
N Terminal Sequence
Ala
AA Sequence
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