Recombinant human BCAM protein
BCAM, also known as Basal cell adhesion molecule isoform 1, is an immunoglobulin superfamily protein that arises from alternate splicing of the Lutheran blood group molecule. This protein is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. Also, it interacts with integrin in sickle red cells, and may potentially play a role in vaso-occlusive episodes. Recombinant human BCAM, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Basal cell adhesion molecule isoform 1, BCAM, AU, CD239, LU, MSK19
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
83.2 kDa (755aa)
Additionnal Information
References & Citations
An X., et al, (2008) Blood 112:5212-5218.; ; El Nemer W., et al, (2001) J. Biol. Chem. 276:23757-23762.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_005572
Uniprot Accession Number
P50895
Species
Human
N Terminal Sequence
Glu32
AA Sequence
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