Recombinant human CD320/TCblR/8D6A protein
CD320, also known as CD320 antigen isoform 1, belongs to the low-density lipoprotein receptor family, with 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region. It binds TC- cobalamin (Cbl) and internalizes the complex by endocytosis. It is known to enhance proliferation of germinal center (GC) B cells and follicular dendritic cells. It augments the proliferation of PC precursors generated by IL-10. It collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055. Recombinant human CD320, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CD320 antigen isoform 1, CD320, 8D6, 8D6A, TCBLR
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
47.4 kDa (438aa)
Additionnal Information
References & Citations
Quadros EV., et al. (2009) Blood. 113:186-192.; ; Zhang X., et al. (2001) J Immunol. 167:49-56.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_057663
Uniprot Accession Number
Q9NPF0
Species
Human
N Terminal Sequence
Leu31
Frequently Asked Questions
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