Recombinant human CD1a protein

CD1A, also known as T-cell surface glycoprotein CD1a isoform 1, is the CD1 family of transmembrane glycoproteins. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. Also, it is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Recombinant human CD1A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

T-cell surface glycoprotein CD1a isoform 1, CD1A, CD1, FCB6, HTA1, R4, T6

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

33.2 kDa (291aa)

Additionnal Information

CD1a, T-cell surface glycoprotein CD1a isoform 1, CD1A, CD1, FCB6, HTA1, R4, T6, ATGP3594-10 µg, ATGP3594-20 µg, ATGP3594-50 µg, ATGP3594-100 µg, ATGP3594-250 µg, ATGP3594-500 µg, ATGP3594-1 mg, ATGP3594-10, ATGP3594-20, ATGP3594-50, ATGP3594-100, ATGP3594-250, ATGP3594-500, ATGP3594-1

References & Citations

West JA., et al, (2014) PLoS ONE 9:E109586.; ; Seshadri C., et al, (2014) Genes Immun. 15:195-198.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001754

Uniprot Accession Number

P06126

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H