Recombinant human CD301/CLEC10A protein

CLEC10A, also known as C-type lectin domain family 10 member A isoform 2, is a C-type lectin superfamily member 14. It is expressed on immature myeloid dendritic cells and alternatively activated macrophages. This protein roles in regulating adaptive and innate immune responses. Also, it binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine, linked to serine or threonine. Recombinant human CLEC10A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-type lectin domain family 10 member A isoform 2, CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, Macrophage lectin 2

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.3 kDa (241aa)

Additionnal Information

CLEC10A, CD301, C-type lectin domain family 10 member A isoform 2, CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, ATGP3591-10 µg, ATGP3591-20 µg, ATGP3591-50 µg, ATGP3591-100 µg, ATGP3591-250 µg, ATGP3591-500 µg, ATGP3591-1 mg, ATGP3591-10, ATGP3591-20, ATGP3591-50, ATGP3591-100, ATGP3591-250, ATGP3591-500, ATGP3591-1

References & Citations

Lenos K., et al, (2015) Oncotarget 6:26278-26290.; ; Zizzari IG., et al, (2015) PLoS ONE 10:E0132617.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Scientific Category

Immunology

NCBI Accession Number

NP_006335

Uniprot Accession Number

Q8IUN9

Species

Human

N Terminal Sequence

Ala

AA Sequence

QNSKFQR DLVTLRTDFS NFTSNTVAEI QALTSQGSSL EETIASLKAE VEGFKQERQA VHSEMLLRVQ QLVQDLKKLT CQVATLNNNG EEASTEGTCC PVNWVEHQDS CYWFSHSGMS WAEAEKYCQL KNAHLVVINS REEQNFVQKY LGSAYTWMGL SDPEGAWKWV DGTDYATGFQ NWKPGQPDDW QGHGLGGGED CAHFHPDGRW NDDVCQRPYH WVCEAGLGQT SQES