Recombinant human PKA C-alpha/PRKACA protein
PRKACA, also known as cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1, is a member of the Ser/Thr protein kinase family. It is responsible for phosphorylating other proteins and substrates, changing their activity. This protein is a member of the AGC kinase family, and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. Recombinant human PRKACA protein, fused to GST-tag at N-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1, PRKACA, PKACA, PPNAD4
Expression System
Baculovirus
Antigen Species
Human
Tag
GST-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
67 kDa (578aa)
Additionnal Information
References & Citations
Moody SE. et al., (2015) Oncogene. 34: 2061-2071.; ; Nanba K. et al., (2016) Eur J Endocrinol. 175: K1-6.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002721
Uniprot Accession Number
P17612
Species
Human
N Terminal Sequence
Met
AA Sequence
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