Recombinant human PD-L2/B7-DC protein

PDCD1LG2, also known as programmed cell death 1 ligand 2, which belongs to the immunoglobulin superfamily or TN/MOG family. This protein is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Also, it interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Recombinant human PDCD1LG2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Programmed cell death 1 ligand 2, PDCD1LG2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

47.7 kDa (423aa)

Additionnal Information

PD-L2, B7-DC, Programmed cell death 1 ligand 2, PDCD1LG2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2, ATGP3571-10 µg, ATGP3571-20 µg, ATGP3571-50 µg, ATGP3571-100 µg, ATGP3571-250 µg, ATGP3571-500 µg, ATGP3571-1 mg, ATGP3571-10, ATGP3571-20, ATGP3571-50, ATGP3571-100, ATGP3571-250, ATGP3571-500, ATGP3571-1

References & Citations

Xu J., et al, (2016) Am. J. Surg. Pathol. 40:443-453.; ; Latchman Y., et al, (2001) Nat. Immunol. 2:261-268.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_079515

Uniprot Accession Number

Q9BQ51

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPLFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH