Recombinant canine IL-31 protein
IL31, also known as interleukin 31, is a member of the gp130/interleukin-6 cytokine family that is produced by cell types such as T helper 2 lymphocytes and cutaneous lymphocyte antigen positive skin homing T cells. IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta) . The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. Recombinant canine IL31, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-31, IL-31
Expression System
Baculovirus
Antigen Species
Canine
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
16.1 kDa (142aa)
Additionnal Information
References & Citations
MizunoT., et al, (2009) Vet. Immunol. Immunopathol. 131:140-143.; ; Gonzales AJ., et al, (2013) Vet. Dermatol. 24:48-53.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001159386
Uniprot Accession Number
C7G0W1
Species
Canine
N Terminal Sequence
Ser24
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