Recombinant human CD200 protein
CD200, also known as OX-2 membrane glycoprotein isoform a, is a transmembrane immuno- regulatory protein that belongs to the immunoglobulin superfamily. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. Recombinant human CD200 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
OX-2 membrane glycoprotein isoform a, CD200, MOX1, MOX2, MRC, OX-2
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA Assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
49.7 kDa (444aa)
Additionnal Information
References & Citations
Akkaya M., et al. (2013) PLoS One. 8:e63325.; ; Li L., et al. (2016) Med Sci Monit. 22:1079-1084.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_005935
Uniprot Accession Number
P41217
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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