Recombinant human CD200 protein

CD200, also known as OX-2 membrane glycoprotein isoform a, is a transmembrane immuno- regulatory protein that belongs to the immunoglobulin superfamily. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. Recombinant human CD200 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

OX-2 membrane glycoprotein isoform a, CD200, MOX1, MOX2, MRC, OX-2

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by BCA Assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

49.7 kDa (444aa)

Additionnal Information

CD200, OX-2 membrane glycoprotein isoform a, CD200, MOX1, MOX2, MRC, OX-2, ATGP3557-10 µg, ATGP3557-20 µg, ATGP3557-50 µg, ATGP3557-100 µg, ATGP3557-250 µg, ATGP3557-500 µg, ATGP3557-1 mg, ATGP3557-10, ATGP3557-20, ATGP3557-50, ATGP3557-100, ATGP3557-250, ATGP3557-500, ATGP3557-1

References & Citations

Akkaya M., et al. (2013) PLoS One. 8:e63325.; ; Li L., et al. (2016) Med Sci Monit. 22:1079-1084.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_005935

Uniprot Accession Number

P41217

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH