Recombinant mouse VAMP-2 protein
Vamp2, also known as Vesicle-associated membrane protein 2, is involved in the targeting and/or fusion of transport vesicles to their target membrane. It modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Vamp2 proteins localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a C-terminal. This proteins also known to mediate cAMP-stimulated exocytosis in nerve cells and in renal cells of the juxtaglomerular apparatus. Recombinant mouse Vamp2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography
Product Specifications
Product Name Alternative
Vesicle-associated membrane protein 2, Syb-2, sybII
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
12.8 kDa (118aa) Confirmed by MALDI-TOF
Additionnal Information
References & Citations
Scales SJ., et al. (2002) J Biol Chem. 277 (31) :28271-9.; ; Mendez M., et al. (2011) J Biol Chem. 286 (32) :28608-18
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM EDTA, 0.1mM PMSF, 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_033523.1
Uniprot Accession Number
P63044
Species
Mouse
AA Sequence
MSATAA TVPPAAPAGE GGPPAPPPNL TSNRRLQQTQ AQVDEVVDIM RVNVDKVLER DQKLSELDDR ADALQAGASQ FETSAAKLKR KYWWKNLK
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