Recombinant human TSPAN7 protein
TSPAN7, as known as tetraspanin-7, is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Also, it is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. More recently, it has been identified as a key immune system target in type 1 diabetes. Recombinant human TSPAN7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tetraspanin-7, TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
12.6 kDa (110aa)
Additionnal Information
References & Citations
Wuttig D., et al, (2012) Int. J. Cancer 131:e693-704.; ; Bassani S., et al, (2012) Neuron 73:1143-1158.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_004606
Uniprot Accession Number
P41732
Species
Human
N Terminal Sequence
Ala
AA Sequence
RHEIKDT FLRTYTDAMQ TYNGNDERSR AVDHVQRSLS CCGVQNYTNW STSPYFLEHG IPPSCCMNET DCNPQDLHNL TVAATKVNQK GCYDLVTSFM ETNM
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