Recombinant human CD84/SLAMF5 protein

CD84, also known as slam family member 5 isoform 1, is a self-binding receptor from the CD150 family that is broadly expressed in hematopoietic cells. It is highly expressed in mast cells and that it contributes to the regulation of FCER1 signaling in SAP- and EAT-2-independent and Fes- and Src homology region 2 domain-containing phosphatase-1-dependent mechanisms. It belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells. Its expression is significantly elevated from the early stages of the disease, and is regulated by macrophage migration inhibitory factor and its receptor, CD74. Recombinant human CD84, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

SLAM family member 5 isoform 1, CD84, hCD84, LY9B, mCD84, SLAMF5

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

23.8 kDa (213aa)

Additionnal Information

CD84, SLAMF5, SLAM family member 5 isoform 1, CD84, hCD84, LY9B, mCD84, SLAMF5, ATGP3548-10 µg, ATGP3548-20 µg, ATGP3548-50 µg, ATGP3548-100 µg, ATGP3548-250 µg, ATGP3548-500 µg, ATGP3548-1 mg, ATGP3548-10, ATGP3548-20, ATGP3548-50, ATGP3548-100, ATGP3548-250, ATGP3548-500, ATGP3548-1

References & Citations

Binsky-Ehrenreich I., et al. (2014) Oncogene. 33:1006-1016.; ; Alvarez-Errico D., et al. (2011) J Immunol. 187:5577-5586.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001171808.1

Uniprot Accession Number

Q9UIB8

Species

Human

N Terminal Sequence

Ala

AA Sequence

KDSEIFT VNGILGESVT FPVNIQEPRQ VKIIAWTSKT SVAYVTPGDS ETAPVVTVTH RNYYERIHAL GPNYNLVISD LRMEDAGDYK ADINTQADPY TTTKRYNLQI YRRLGKPKIT QSLMASVNST CNVTLTCSVE KEEKNVTYNW SPLGEEGNVL QIFQTPEDQE LTYTCTAQNP VSNNSDSISA RQLCADIAMG FRTHHTG