Recombinant human CD66e/CEACAM5 protein
CEACAM5, as known as carcinoembryonic antigen-related cell adhesion molecule 5, is the large CEACAM subfamily of immunoglobulin superfamily. This protein can mediate cell to cell adhesion through homotypic and heterotypic interactions. It is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumors. Also, it is upregulated in a wide variety of human tumors and is a commonly used cancer marker. Recombinant human CEACAM5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Carcinoembryonic antigen-related cell adhesion molecule 5, CEACAM5, CD66e, CEA, CEA cell adhesion molecule 5
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
72.3 kDa (659aa)
Additionnal Information
References & Citations
Filiberti R., et al, (2013) Med. Oncol. 30:543.; ; Jurgensmeier JM., et al, (2013) Br. J. Cancer 108:1316-1323.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_004354
Uniprot Accession Number
P06731
Species
Human
N Terminal Sequence
Lys35
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