Recombinant human Relaxin-2 protein
RLN2, as known as prorelaxin H2 isoform 1, belongs to the insulin gene superfamily. This family is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. It is 18 kDa in size and 185 aa in length. It contains a 24 aa signal sequence, a 3. 3 kDa, 29 aa B domain, a 106 aa C (or connecting) domain, and a C-terminal, 2. 7 kDa, 24 aa A domain. Recombinant human RLN2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Prorelaxin H2 isoform 1, RLN2, bA12D24.1.1, bA12D24.1.2, H2, H2-RLX, RLXH2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
19.3 kDa (170aa)
Additionnal Information
References & Citations
Ng TM., et al, (2016) Cardiol Rev. 24:194-204.; ; Sherwood OD., et al, (2004) Endocr. Rev. 25:205-234.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_604390
Uniprot Accession Number
P04090
Species
Human
N Terminal Sequence
Ala
AA Sequence
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