Recombinant human ALK-3/BMPR1A protein

BMPR1A, also known as bone morphogenetic protein receptor type-1A, is secreted cytokines/growth factors belonging to the Transforming Growth Factor beta (TGFbeta) family. It has been shown to be overexpressed in human breast cancers. Its deletion impairs mammary tumor formation and metastasis. It plays important roles in the differentiation and development of neurons. Its expression is up-regulated during bone formation, and that they may play important roles in bone morphogenesis. Recombinant human BMPR1A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Bone morphogenetic protein receptor type 1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, ACVRLK3, ALK3

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

41.4 kDa (371aa)

Additionnal Information

BMPR-IA, ALK3, Bone morphogenetic protein receptor type-1A, BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, ATGP3541-10 µg, ATGP3541-20 µg, ATGP3541-50 µg, ATGP3541-100 µg, ATGP3541-250 µg, ATGP3541-500 µg, ATGP3541-1 mg, ATGP3541-10, ATGP3541-20, ATGP3541-50, ATGP3541-100, ATGP3541-250, ATGP3541-500, ATGP3541-1

References & Citations

Pickup MW., et al. (2015) Oncotarget. 6:22890-22904.; ; Wang W., et al. (2014) Int J Clin Exp Pathol. 7:2312-2318.; ; Ishidou Y., et al. (1995) J Bone Miner Res. 10:1651-1659.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_004320

Uniprot Accession Number

P36894

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H