Recombinant human CD5 protein

CD5, as known as T-cell surface glycoprotein CD5, is a transmembrane glycoprotein in the scavenger receptor superfamily. This protein was found expressed in small lymphocytic lymphoma, hairy cell leukemia and mantle cell lymphoma cells. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor and is up-regulated peripheral CD4+ cell. Also, its Signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Recombinant human CD5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

T-cell surface glycoprotein CD5, CD5, LEU1, T1

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

40kDa (359aa)

Additionnal Information

CD5, T-cell surface glycoprotein CD5, CD5, LEU1, T1, ATGP3534-10 µg, ATGP3534-20 µg, ATGP3534-50 µg, ATGP3534-100 µg, ATGP3534-250 µg, ATGP3534-500 µg, ATGP3534-1 mg, ATGP3534-10, ATGP3534-20, ATGP3534-50, ATGP3534-100, ATGP3534-250, ATGP3534-500, ATGP3534-1

References & Citations

Cenit MC., et al, (2014) PLoS ONE 9:E113090.; ; Alinari L., et al, (2016) Am. J. Hematol. 91:395-399.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_055022

Uniprot Accession Number

P06127

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPEFRLSWY DPDFQARLTR SNSKCQGQLE VYLKDGWHMV CSQSWGRSSK QWEDPSQASK VCQRLNCGVP LSLGPFLVTY TPQSSIICYG QLGSFSNCSH SRNDMCHSLG LTCLEPQKTT PPTTRPPPTT TPEPTAPPRL QLVAQSGGQH CAGVVEFYSG SLGGTISYEA QDKTQDLENF LCNNLQCGSF LKHLPETEAG RAQDPGEPRE HQPLPIQWKI QNSSCTSLEH CFRKIKPQKS GRVLALLCSG FQPKVQSRLV GGSSICEGTV EVRQGAQWAA LCDSSSARSS LRWEEVCREQ QCGSVNSYRV LDAGDPTSRG LFCPHQKLSQ CHELWERNSY CKKVFVTCQD PNPHHHHHH